PUBLICATIONS
References and Links to Papers
(43) Mechanistic Insights into Polymerization-Induced Self-Assembly Using Maleimide-Based Fluorophores. AK Pearce, SJ Parkinson, I Akar, MJ Derry, PD Topham, RT Mathers, VG Stavros, RK O’Reilly, Macromolecules, 2023, 56, 23, 9443–9454
(42) Preparation of functional nanoparticles of mPEG-b-P(DMA-co-HA) copolymers via polymerization-induced thermal self-assembly. I Akar, AK Pearce, CMS Kumar, C Ferguson, RK O'Reilly, Journal of Polymer Science, 2023, 61, 22, 2932
(41) Chain-Extension in Hyperbranched Polymers Alters Tissue Distribution and Cytotoxicity Profiles in Orthotopic Models of Triple Negative Breast Cancers, C Moloney, F Mehradnia, RJ Cavanagh, A Ibrahim, AK Pearce, A Ritchie, P Clarke, R Rahman, AM Grabowska, C Alexander. Biomaterials Science, 2023, 11, 6545-6560
(40) Elucidating the role of multivalency, shape, size and functional group density on antibacterial activity of diversified supramolecular nanostructures enabled by templated assembly. A Sikder, AK Pearce, CMS Kumar, RK O’Reilly, Materials Horizons, 2023, 10 (1), 171-178
(39) Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers. F Mehradnia, C Moloney, RJ Cavanagh, AK Pearce, A Ritchie, P Clarke, R Rahman, A Ibrahim, AM Grabowska, C Alexander, British Journal of Pharmacy, 2022, 7 (2), S1-S2
(38) Enhancing Dual‐State Emission in Maleimide Fluorophores through Fluorocarbon Functionalisation, M Pervez, AK Pearce, JT Husband, L Male, M Torrent‐Sucarrat, RK O'Reilly, Chemistry–A European Journal, 2022, 28 (58), e202201877
(37) Log Poct/SA Predicts the Thermoresponsive Behavior of P(DMA-co-RA) Statistical Copolymers, I Akar, JC Foster, X Leng, AK Pearce, RT Mathers, RK O’Reilly, ACS Macro Letters, 2022, 11 (4), 498-503
(36) Uniform antibacterial cylindrical nanoparticles for enhancing the strength of nanocomposite hydrogels, Z Li, AK Pearce, J Du, AP Dove, RK O'Reilly, Journal of Polymer Science, 2023, 61 (1), 44
(35) Synthesis, characterisation and evaluation of hyperbranched N-(2-hydroxypropyl) methacrylamides for transport and delivery in pancreatic cell lines in vitro and in vivo, AB Anane-Adjei, NL Fletcher, RJ Cavanagh, ZH Houston, T Crawford, AK Pearce, V Taresco, AA Ritchie, P Clarke, AM Grabowska, PR Gellert, MB Ashford, B Kellam, KJ Thurecht, C Alexander, Biomaterials Science, 2022, 10 (9), 2328-2344
(34) Polymers for biomedical applications: the importance of hydrophobicity in directing biological interactions and application efficacy, AK Pearce, RK O’Reilly, Biomacromolecules, 2021, 22 (11), 4459-4469
(33) Poly (glycerol adipate)(PGA) backbone modifications with a library of functional diols: Chemical and physical effects, PL Jacob, LAR Cantu, AK Pearce, Y He, JC Lentz, JC Moore, F Machado, G Rivers, E Apebende, MR Fernandez, I Francolini, R Wildman, SM Howdle, V Taresco, Polymer, 2021, 228, 123912
(32) Precise tuning of polymeric fiber dimensions to enhance the mechanical properties of alginate hydrogel matrices, Z Li, AK Pearce, AP Dove, RK O’Reilly, Polymers, 2021, 13 (13), 2202
(31) Recent trends in advanced polymer materials in agriculture related applications, A Sikder, AK Pearce, SJ Parkinson, R Napier, RK O’Reilly, ACS Applied Polymer Materials, 2021, 3 (3), 1203-1217
(30) Effect of heterogeneous and homogeneous polymerisation on the structure of pNIPAm nanogels, A Vdovchenko, AK Pearce, M Freeley, RK O'Reilly, M Resmini, Polymer Chemistry, 2021, 12 (47), 6854-6864
(29) Synthesis and applications of anisotropic nanoparticles with precisely defined dimensions, AK Pearce, TR Wilks, MC Arno, RK O’Reilly, Nature Reviews Chemistry, 2021, 5 (1), 21-45
(28) Synthesis of cytotoxic spirocyclic imides from a biomass-derived oxanorbornene, SB Lawrenson, AK Pearce, S Hart, AC Whitwood, RK O’Reilly, M North, Tetrahedron, 2021, 77, 131754
(27) Functionalized Block Co‐Polymer Pro‐Drug Nanoparticles with Anti‐Cancer Efficacy in 3D Spheroids and in an Orthotopic Triple Negative Breast Cancer Model, V Taresco, TF Abelha, RJ Cavanagh, CE Vasey, AB Anane‐Adjei, AK Pearce, PF Monteiro, KA Spriggs, P Clarke, A Ritchie, S Martin, R Rahman, AM Grabowska, MB Ashford, C Alexander, Advanced Therapeutics, 2021, 4 (1), 2000103
(26) Probing and tuning the permeability of polymersomes, AJ Miller, AK Pearce, JC Foster, RK O’Reilly, ACS Central Science, 2020, 7 (1), 30-38
(25) 100th anniversary of macromolecular science viewpoint: The role of hydrophobicity in polymer phenomena, JC Foster, I Akar, MC Grocott, AK Pearce, RT Mathers, RK O’Reilly, ACS Macro Letters, 2020, 9 (11), 1700-1707
(24) Effects of polymer 3D architecture, size, and chemistry on biological transport and drug delivery in vitro and in orthotopic triple negative breast cancer models, AK Pearce, AB Anane‐Adjei, RJ Cavanagh, PF Monteiro, TM Bennett, V Taresco, PA Clarke, AA Ritchie, MR Alexander, AM Grabowska, C Alexander, Advanced Healthcare Materials, 2020, 9 (22), 2000892
(23) Antimicrobial hyperbranched polymer–usnic acid complexes through a combined ROP‐RAFT strategy, M Rauschenbach, SB Lawrenson, V Taresco, AK Pearce, RK O'Reilly, Macromolecular Rapid Communications, 2020, 41 (18), 2000190
(22) Functional initiators for the ring‐opening polymerization of polyesters and polycarbonates: An overview, H Phan, K Kortsen, G Englezou, B Couturaud, AJ Nedoma, AK Pearce, V Taresco, Journal of Polymer Science, 2020, 58 (14), 1911-1923
(21) Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer, PF Monteiro, M Gulfam, CJ Monteiro, A Travanut, TF Abelha, AK Pearce, C Jerôme, AM Grabowska, PA Clarke, HM Collins, DM Heery, P Gershkovich, C Alexander, Journal of Controlled Release, 2020, 323, 549-564
(20) Poly (glycerol adipate): From a functionalized nanocarrier to a polymeric-prodrug matrix to create amorphous solid dispersions, D Gordhan, SME Swainson, AK Pearce, ID Styliari, T Lovato, JC Burley, MC Garnett, V Taresco, Journal of Pharmaceutical Sciences, 2020, 109 (3), 1347-1355
(19) Development of Pyrazolo[3,4-d]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme
C Greco, V Taresco, AK Pearce, CE Vasey, S Smith, R Rahman, C Alexander, RJ Cavanagh, F Musumeci, S Schenone, ACS Medicinal Chemistry Letters, 2020, 11 (5), 657-663
(18) Starch/poly (glycerol-adipate) nanocomposites: A novel oral drug delivery device, A Vestri, AK Pearce, R Cavanagh, ID Styliari, C Sanders, B Couturaud, S Schenone, V Taresco, RR Jakobsen, SM Howdle, F Musumeci, D Sagnelli, Coatings, 2020, 10 (2), 125
(17) Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide, F Sodano, RJ Cavanagh, AK Pearce, L Lazzarato, B Rolando, A Fraix, TF Abelha, CE Vasey, C Alexander, V Taresco, S Sortino, Biomaterials Science, 2020, 8 (5), 1329-1344
(16) Versatile, Highly Controlled Synthesis of Hybrid (Meth) acrylate–Polyester–Carbonates and their Exploitation in Tandem Post‐Polymerization–Functionalization, AK Pearce, CE Vasey, AB Anane‐Adjei, F Sodano, VC Crucitti, DJ Irvine, SM Howdle, C Alexander, V Taresco, Macromolecular Chemistry and Physics, 2019, 220 (21), 1900270
(15) Role of self‐assembly conditions and amphiphilic balance on nanoparticle formation of PEG‐PDLLA copolymers in aqueous environments, H Phan, RI Minut, P McCrorie, C Vasey, RR Larder, E Krumins, M Marlow, R Rahman, C Alexander, V Taresco, AK Pearce, Journal of Polymer Science Part A: Polymer Chemistry, 2019, 57 (17), 1801-1810
(14) Exploring the enzymatic degradation of poly (glycerol adipate), SME Swainson, V Taresco, AK Pearce, LH Clapp, B Ager, M McAllister, C Bosquillon, MC Garnett, European Journal of Pharmaceutics and Biopharmaceutics, 2019, 142, 377-386
(13) Insights into active targeting of nanoparticles in drug delivery: Advances in clinical studies and design considerations for cancer nanomedicine, AK Pearce, RK O’Reilly, Bioconjugate Chemistry, 2019, 30 (9), 2300-2311
(12) Recent developments in entropy‐driven ring‐opening metathesis polymerization: Mechanistic considerations, unique functionality, and sequence control, AK Pearce, JC Foster, RK O'Reilly, Journal of Polymer Science Part A: Polymer Chemistry, 2019, 57 (15), 1621-1634
(11) Amphiphilic tri-and tetra-block co-polymers combining versatile functionality with facile assembly into cytocompatible nanoparticles, CE Vasey, AK Pearce, F Sodano, R Cavanagh, T Abelha, VC Crucitti, AB Anane-Adjei, M Ashford, P Gellert, V Taresco, C Alexander, Biomaterials Science, 2019, 7 (9), 3832-3845
(10) Synthesis of Methacrylate‐Terminated Block Copolymers with Reduced Transesterification by Controlled Ring‐Opening Polymerization, LA Ruiz‐Cantu, AK Pearce, L Burroughs, TM Bennett, CE Vasey, R Wildman, DJ Irvine, C Alexander, V Taresco, Macromolecular Chemistry and Physics, 2018, 220 (2), 1800459
(9) Clean Block Copolymer Microparticles from Supercritical CO2: Universal Templates for the Facile and Scalable Fabrication of Hierarchical Mesostructured Metal Oxides, TM Bennett, G He, RR Larder, MG Fischer, GA Rance, MW Fay, AK Pearce, CDJ Parmenter, U Steiner, SM Howdle, Nano Letters, 2018, 18 (12), 7560-7569
(8) Functional polymers for drug delivery: Prospects and challenges, AK Pearce, AJ Blok, G Yilmaz, N Singh, RJ Cavanagh, T Abelha, V Taresco, C Alexander, Chimica Oggi/Chemistry Today, 2018, 36 (6), 38-42
(7) Stimuli‐responsive prodrug chemistries for drug delivery, V Taresco, C Alexander, N Singh, AK Pearce, Advanced Therapeutics, 2018. 1 (4), 1800030
(6) High‐Throughput Miniaturized Screening of Nanoparticle Formation via Inkjet Printing, ID Styliari, C Conte, AK Pearce, A Hüsler, RJ Cavanagh, MJ Limo, D Gordhan, A Nieto‐Orellana, J Suksiriworapong, B Couturaud, P Williams, AL Hook, MR Alexander, MC Garnett, C Alexander, JC Burley, V Taresco, Macromolecular Materials and Engineering, 2018, 303 (8), 1800146
(5) Versatile routes to functional raft chain transfer agents through the passerini multicomponent reaction, AK Pearce, A Travanut, B Couturaud, V Taresco, SM Howdle, MR Alexander, C Alexander, ACS Macro Letters, 2017, 6 (7), 781-785
(4) Localised delivery of doxorubicin to prostate cancer cells through a PSMA-targeted hyperbranched polymer theranostic, AK Pearce, JD Simpson, NL Fletcher, ZH Houston, AV Fuchs, PJ Russell, AK Whittaker, KJ Thurecht, Biomaterials, 2017, 141, 330-339
(3) Targeting Nanomedicines to Prostate Cancer: Evaluation of Specificity of Ligands to Two Different Receptors In Vivo, AK Pearce, AV Fuchs, NL Fletcher, KJ Thurecht, Pharmaceutical Research, 2016, 33, 2388-2399
(2) Evaluation of polymeric nanomedicines targeted to PSMA: effect of ligand on targeting efficiency, AV Fuchs, BWC Tse, AK Pearce, MC Yeh, NL Fletcher, SS Huang, WD Heston, AK Whittaker, PJ Russell, KJ Thurecht, Biomacromolecules, 2015, 16 (10), 3235-3247
(1) Development of a polymer theranostic for prostate cancer, AK Pearce, BE Rolfe, PJ Russell, BWC Tse, AK Whittaker, AV Fuchs, KJ Thurecht, Polymer Chemistry, 2014, 5 (24), 6932-6942